Cisplatin resistance in head and neck squamous cell carcinoma (HNSCC) reduces survival.In this study we hypothesized that methylation of key genes mediates cisplatin resistance.We determined whether a demethylating drug, decitabine, could augment the anti-proliferative and apoptotic effects of cisplatin on SCC-25/CP, a cisplatin-resistant tongue SC
This research sought to find a potent drug for the treatment of acne from six (6) flavones.DFT-B3LYP method was used to determine the molecular descriptors like HOMO, LUMO, Dipole moment, and volume of the ligands and standard drugs.SWISSADMET was employed to ascertain the pharmacokinetic properties of berness white sneakers the ligands, and molecu
Representation learning has proven to be a powerful methodology in a wide variety of machine-learning applications.For atmospheric dynamics, however, it has so far not been considered, arguably due to the lack of large-scale, labeled datasets that could be used for training.In this work, we show how to sidestep the sophie allport zebra difficulty a
IntroductionConventional MRI is routinely used for the characterization of pathological changes in multiple sclerosis (MS), but due to its lack of specificity click here is unable to provide accurate prognoses, explain disease heterogeneity and reconcile the gap between observed clinical symptoms and radiological evidence.Quantitative MRI provides